Protective effects of Moringa oleifera seed Extracts on Nutmeg induced Kidney Toxicity in Wistar Rats
1,2,3 Ozor Ignatius Ikemefuna; 1Okpala Onyedikachukwu Precious; 1,2Ugwu Valentine Ifebuchechukwu; 1Uzoefuna Chima Casmir and 1Nnachi Ifenna Salvator
1Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, State University of Medical and Applied sciences (SUMAS), Igbo-Eno, Enugu State, Nigeria.
2Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, Enugu State University of Science and Technology (ESUT), Enugu, Nigeria.
3Department of Surgery, Faculty of Clinical Medicine, College of Medicine, Enugu State University of Science and Technology, Enugu, Nigeria.
Corresponding author: Ugwu, Valentine Ifebuchechukwu (valentineugwu66@gmail.com, valentine.ugwu@sumas.edu.ng, +2348136236747)
ABSTRACT
Nutmeg is a popular household spices that has a serious health effect when abused, and has been found to have a very serious toxic effects on the kidney. This study investigated the protective potency of Moringa oleifera seed extracts on nutmeg induced nephrotoxicity. This study made use of twenty-four (24) Wistar rats weighing between 80-150g, which was randomly selected into six groups. Group A received no treatment while Group B was administered 500 mg/kg of nutmeg seed extract. Group C received 500 mg/kg of nutmeg seed extract and 200mg/kg of moringa ethanolic seed extract. Group D was administered 500 mg/kg of nutmeg seed extract and 400mg/kg of moringa ethanolic seed extract. Group E was administered 500 mg/kg of nutmeg seed extract and 200mg/kg of moringa n-hexane seed extract. Group F was also administered 500 mg/kg of nutmeg seed extract and 400mg/kg of moringa n-hexane seed extract. From the histological analysis, the photomicrographs of groups B, C and E showed significant renal damage, while groups A, D and F showed normal kidney histoarchitecture with intact glomeruli and convoluted tubules.The results from this study confirmed the protective potency of Moringa on nutmeg induced kidney toxicity at the histological level. However, further research is encouraged.
Keywords: Nutmeg Toxicity, Nephrotoxicity, Moringa oleifera, Kidney Damage, Renal Dysfunction, Protective Potency and Wistar Rats
CITE AS: Ozor Ignatius Ikemefuna; Okpala Onyedikachukwu Precious; Ugwu Valentine Ifebuchechukwu; Uzoefuna Chima Casmir and Nnachi Ifenna Salvator (2025). Protective effects of Moringa oleifera seed Extracts on Nutmeg induced Kidney Toxicity in Wistar Rats. NEWPORT INTERNATIONAL JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES, 6(1): 32-35. https://doi.org/10.59298/NIJBAS/2025/6.1.323500