Nanotechnology-Based Targeting of Adipose Tissue Inflammation in Obesity: Mechanisms, Challenges, and Therapeutic Opportunities
Serunjogi Ruth
Department of Clinical Pharmacy Kampala International University Uganda
Email: ruth.serunjogi@studwc.kiu.ac.ug
ABSTRACT
Obesity is characterized by chronic low-grade inflammation within adipose tissue, which plays a central role in the development of insulin resistance, type 2 diabetes, cardiovascular disease, and other metabolic complications. Conventional anti-inflammatory and metabolic therapies often lack tissue specificity, leading to limited efficacy and systemic side effects. Nanotechnology has emerged as a powerful platform to overcome these limitations by enabling targeted delivery of therapeutic agents directly to inflamed adipose tissue. Nanocarriers can be engineered to exploit adipose tissue vascularization, immune cell infiltration, and molecular signatures associated with obesity-induced inflammation. This review provides a comprehensive overview of nanotechnology-based strategies for targeting adipose tissue inflammation in obesity. We discuss the underlying mechanisms of adipose tissue inflammation, design principles of nanocarriers, and current nanotherapeutic approaches, including drug-loaded nanoparticles, gene delivery systems, and biomimetic platforms. Key challenges such as biological barriers, safety, scalability, and regulatory considerations are critically examined. Finally, we highlight emerging therapeutic opportunities and future directions for translating nanotechnology-driven adipose tissue targeting into clinically viable obesity treatments.
Keywords: nanotechnology; obesity; adipose tissue; inflammation; targeted therapy.
CITE AS: Serunjogi Ruth (2026). Nanotechnology-Based Targeting of Adipose Tissue Inflammation in Obesity: Mechanisms, Challenges, and Therapeutic Opportunities. NEWPORT INTERNATIONAL JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES, 7(2):66-71.
https://doi.org/10.59298/NIJSES/2026/72.6671