Nanoparticle Mediated Modulation of Adipose Tissue Inflammation in Obesity-Induced Insulin Resistance

Kamanzi Ntakirutimana G.

School of Natural and Applied Sciences Kampala International University Uganda

                                                                                                     ABSTRACT
Obesity-induced insulin resistance (IR) is a major contributor to the pathogenesis of type 2 diabetes (T2D) and is largely driven by chronic low-grade inflammation in adipose tissue. Adipose tissue inflammation not only impairs insulin signaling but also exacerbates metabolic disturbances by promoting systemic inflammation. Nanotechnology offers innovative approaches to modulate adipose tissue inflammation and improve insulin sensitivity. Nanoparticles (NPs), due to their small size, high surface area, and ability to carry bioactive molecules, can target adipose tissue and specifically reduce inflammation at the molecular level. This review discusses various nanoparticle-mediated strategies for modulating adipose tissue inflammation in obesityinduced insulin resistance, including the use of anti-inflammatory drugs, natural compounds, and RNA-based
therapies. We explore the mechanisms by which nanoparticles enhance drug delivery, their impact on insulin sensitivity, and their potential therapeutic applications. Additionally, the challenges and future perspectives for the clinical translation of these nanotechnologies are highlighted.

Keywords: obesity, insulin resistance, adipose tissue inflammation, nanoparticles, drug delivery.

CITE AS: Kamanzi Ntakirutimana G. (2026). Nanoparticle Mediated Modulation of Adipose Tissue Inflammation in Obesity-Induced Insulin
Resistance. NEWPORT INTERNATIONAL JOURNAL OF RESEARCH IN MEDICAL SCIENCES. https://doi.org/10.59298/NIJRMS/2026/7.1.2530