Hepatic effects of Traumatic Brain Injury using Wistar Rats
1,3,5Ebuoh Maryann Chiamaka; 2Uzoefuna Chima Casmir; 1,3Ugwu Valentine Ifebuchechukwu; 1,3,4Ozor Ignatius Ikemefuna; 5Ani Peace Nkechi; 5Okoli Adaora Ukamaka; 5Ogbuka Janet N; 1Ugbor Chidera Victoria, 1Okpala Precious Onyedika and 5Nwankwo Stella Nneka
1Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, State University of Medical and Applied sciences (SUMAS), Igbo-Eno, Enugu State, Nigeria.
2Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, State University of Medical and Applied sciences (SUMAS), Igbo-Eno, Enugu State, Nigeria.
3Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, Enugu State University of Science and Technology (ESUT), Enugu, Nigeria.
4Department of Surgery, Faculty of Clinical Medicine, College of Medicine, Enugu State University of Science and Technology, Enugu, Nigeria.
5Enugu State College of Nursing Sciences Parklane, Enugu, Nigeria.
Corresponding author: Ebuoh, Maryann Chiamaka (maryann.ebuoh@sumas.edu.ng +2348149560255)
ABSTRACT
Over the years, studies have shown that head injuries can lead to various traumatic effects on the brain. However, these injuries not only impact the brain but also affect the liver. This study examined the histopathological effects of traumatic brain injury (TBI) on the liver. Fifty Wistar rats, weighing between 150g and 250g, were divided into five groups (A–E). Group A served as the negative control, with no trauma induced. Group B received a 50g weight impact on the head, Group C was subjected to a 100g weight, Group D to a 150g weight, and Group E to a 200g weight. The injured animals were sacrificed at intervals of 5 hours, 24 hours, 7 days, and 24 days post-trauma. Their tissues were processed using paraffin embedding and Hematoxylin-Eosin staining. Histological analysis of the control group revealed normal tissue morphology. In contrast, the traumatized groups exhibited pathological changes such as edema, necrosis, apoptosis, gliosis, inflammation, cellular infiltration, and hemorrhage. These findings suggest that TBI indirectly exerts toxic effects on the liver, with the extent of damage correlating to the severity of the trauma.
Keywords: hepatic, traumatic brain injury, peripheral abnormalities, and inflammation
CITE AS: Ebuoh Maryann Chiamaka; Uzoefuna Chima Casmir; Ugwu Valentine Ifebuchechukwu; Ozor Ignatius Ikemefuna; Ani Peace Nkechi; Okoli Adaora Ukamaka; Ogbuka Janet N; Ugbor Chidera Victoria, Okpala Precious Onyedika and Nwankwo Stella Nneka (2025). Hepatic effects of Traumatic Brain Injury using Wistar Rats. NEWPORT INTERNATIONAL JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES, 6(2):31-36. https://doi.org/10.59298/NIJSES/2025/62.313600