Effects of Ethanolic Extract of Vinegar Leaf (Andrographis paniculata) on Blood Sugar Level of Alloxan-Induced Diabetic Albino Rat (Rattus norvegicus)
1Zitte Leelee Famii, 1Iro Chika Eke and 2Agbeyi Erhomarhua Victor
1Department of Animal and Environmental Biology, University of Port Harcourt, Nigeria
2Department of Environmental Management and Toxicology, Faculty of Science Dennis Osadebay University, Asaba Delta State, Nigeria.
Corresponding Author: leelee.zitte @uniport.edu.ng
ABSTRACT
This study aimed at examining antidiabetic efficacy of ethanolic extract of vinegar leaf on blood sugar level of alloxan-induced diabetic albino rats. 25 male rats of 137-224g body weight were grouped into five groups of five animals per group. Group 1 was used as non-diabetic control, group 2, 3, 4 and 5 were induced with diabetes by administering 150mg/kg of alloxan intraperitoneally. Group 2 served as diabetic control. After 2 days of developing diabetes by group 3, 4, and 5, they were treated with vinegar ethanolic extract at concentrations of 200mg/kg, 400mg/kg, and 800mg/kg respectively. Blood glucose levels were tested at three days intervals. Result indicated that the alloxan-induced diabetic rats expressed hyper-glycemia in group 3, 4 and 5 as against the control of non-diabetic sugar level. When the extract was administered to group 3, 4, and 5 there was a significant reduction in the glucose levels (p<0.05) compared with control group 2 after 12 days. The result also showed that there was a corresponding increase in weight as the sugar level increases (p<0.05) and a decrease in weight as the sugar level decreases. Vinegar leaf has positive hypoglycemic effect and should be recommended for diabetic patients.
Keywords: diabetic, vinegar leaf, alloxan, anti-diabetic, glucose
CITE AS: Zitte Leelee Famii, Iro Chika Eke and Agbeyi Erhomarhua Victor (2025). Effects of Ethanolic Extract of Vinegar Leaf (Andrographis paniculata) on Blood Sugar Level of Alloxan-Induced Diabetic Albino Rat (Rattus norvegicus). NEWPORT INTERNATIONAL JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES. 6(1):40-46. https://doi.org/10.59298/NIJBAS/2025/6.1.404600