Adaptogenic and Antioxidant Properties of Herbal Compounds in Combatting Oxidative Stress in Obesity-Linked Diabetes

Omukisa Kireba K.

Faculty of Science and Technology Kampala International University Uganda

ABSTRACT

Obesity-linked diabetes, also known as diabesity, is a growing global health concern characterized by insulin resistance, chronic inflammation, and oxidative stress. Oxidative stress plays a pivotal role in the pathogenesis of obesity-induced insulin resistance by disrupting cellular homeostasis, impairing pancreatic β-cell function, and promoting pro-inflammatory pathways. Recent evidence suggests that plant-derived bioactive compounds with adaptogenic and antioxidant properties offer promising therapeutic potential in mitigating oxidative stress and its associated metabolic dysfunctions. This review explores the role of oxidative stress in obesity-linked diabetes, highlighting the molecular mechanisms through which herbal compounds exert their adaptogenic and antioxidant effects. Key bioactive phytochemicals, including polyphenols, flavonoids, alkaloids, terpenoids, and saponins, are discussed in the context of their ability to enhance insulin sensitivity, modulate inflammatory responses, and regulate glucose metabolism. Additionally, we examine preclinical and clinical studies demonstrating the efficacy of medicinal plants such as Curcuma longa, Withania somnifera, Panax ginseng, and Camellia sinensis in reducing oxidative damage and improving metabolic outcomes. Understanding the synergistic interactions of these herbal compounds may provide new insights into integrative therapeutic approaches for managing obesity-linked diabetes.

Keywords: Adaptogens, Antioxidants, Obesity-Linked Diabetes, Oxidative Stress, Insulin Resistance, Herbal Medicine, Phytochemicals

CITE AS: Omukisa Kireba K. (2025). Adaptogenic and Antioxidant Properties of Herbal Compounds in Combatting Oxidative Stress in Obesity-Linked Diabetes. Newport International Journal of Research in Medical Sciences,6(2):40-47. https://doi.org/10.59298/NIJRMS/2025/6.2.4047